While I like to shop locally, sometimes online shopping is the way to go.  But searching for things often just brings up Amazon or Ebay, for instance.  It is increasingly hard to find internet-based stores that are not a part of  "Big Tech," or the multinational corporate world domination scheme.  Here are a few of the nicest places I have found to shop online:

Auto and RV Parts:

Rock Auto -- all the parts your car will ever need, based in Madison, WI with warehouses nationwide.
Wild Horses 4x4 -- store in Lodi, CA specializing in parts for Ford Bronco
RVUpgrade Store -- a complete RV supply company based in Eastlake, OH

Books:

Battenkill Books - an independent bookstore in Cambridge, NY
Vroman's Bookstore - in Pasadena, Southern California's Oldest and Largest Independent Bookstore
Biblio.com - Founded in Asheville, NC, Biblio has become a formidable global online book outlet

Health, Medical, Personal and Beauty:

Smallflower - Chicago, IL. Apothecary, personal care, fragrance, vitamins, supplements and more.
Giovanni - based in Medley FL:  eco chic beauty, hair and skin care, also pet shampoos.
Vitality Medical - offers a vast array of medical supplies, equipment, and information. Salt Lake City, UT

Office Supply, Copies and Printing:

DocuCopies - affordable online copy/printing services with western office in San Luis Obispo, CA.
Quill - A major office supply company based in Lincolnshire IL

Clothing, Linens, Jewelry:

SweetUs  - of Concord, CA, offering handcrafted household and wearable textiles, home decor, and more.
JNCO - Yes, the famous Los Angeles based Jeans company from the nineties is still in business!

Home Supplies & Hardware:

Supply House - A New York company with plumbing, heating, electrical, tools and more

Kitchen Supplies and Restaurant Equipment:

Burkette Restaurant Equipment - commercial-grade products at wholesale prices from Toledo OH

Technology

UNIX Surplus - Santa Clara, CA company offering affordable computer components and server gear